Myelin oligodendrocyte glycoprotein (MOG) Human Gene Knockout Kit (CRISPR)

CAT#: KN413662

MOG - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

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Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: Myelin oligodendrocyte glycoprotein
• Locus ID: 4340
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001008228, NM_001008229, NM_001170417, NM_001170418, NM_002433, NM_206809, NM_206810, NM_206811, NM_206812, NM_206813, NM_206814, NM_001363610
• Synonyms: BTN6; BTNL11; MOGIG2; NRCLP7
• Summary: 'The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]'