HNF1 alpha (HNF1A) Mutant (NM_000545) Human Recombinant Protein

CAT#: TP701008

Purified recombinant protein of Human HNF1 homeobox A (HNF1A), mutant (C241S), expressed in HEK293 cells, 20ug

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence: A DNA sequence from TrueORF clone, RC211201, encoding human HNF1A, mutant C241S
• Tag: C-Myc/DDK
• Predicted MW: 67.2 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_000536
• Locus ID: 6927
• Cytogenetics: 12q24.31
• Refseq Size: 3249
• Refseq ORF: 1893
• Synonyms: HNF-1A; HNF1; HNF4A; IDDM20; LFB1; MODY3; TCF-1; TCF1
• Summary: 'The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]'
• Protein Families: Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
• Protein Pathways: Maturity onset diabetes of the young