RIP3 (RIPK3) Mutant (NM_006871) Human Recombinant Protein

CAT#: TP710309

Purified recombinant protein of mutant (K50A) of Human receptor-interacting serine-threonine kinase 3 (RIPK3, K50A mutant), full length, with N-terminal GST and C-terminal His tag, expressed in sf9, 20ug

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: Sf9
• Expression cDNA Clone or AA Sequence: A DNA sequence from TrueORF clone, RC209549, encoding mutant RIPK3(K50A)
• Tag: N-GST
• Predicted MW: 56.7 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50mM Tris-HCl, pH7.4, 20mM Imidazole, 0.3mM DTT, 10% glycerol
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_006862
• Locus ID: 11035
• Cytogenetics: 14q12
• Refseq Size: 1940
• Refseq ORF: 1554
• Synonyms: RIP3
• Summary: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Cytosolic DNA-sensing pathway