Alpha-2-antiplasmin / SERPINF2 Human Protein

CAT#: BA673

Alpha-2-antiplasmin / SERPINF2 human protein, 0.1 mg

Specifications

Product Data

• Species: Human
• Protein Source: Plasma
• Predicted MW: 70 kDa
• Concentration: lot specific
• Purity: >95%
• Buffer: Presentation State: Purified
  State: Lyophilized purified fraction (>95% pure by SDS-PAGE).
  Buffer System: 20 mM BIS-Tris, pH 6.4 containing 200 mM Sodium chloride and no preservative.
• Bioactivity: Specific: 13.05 IU/mg
• Reconstitution: Restore with 31 µl distilled water.
• Preparation: Lyophilized purified fraction (>95% pure by SDS-PAGE).
• Protein Description: Human Alpha 2 Antiplasmin Efficiently inhibits the plasminogen-activator-induced lysis of fibrin clots. Found in plasma in about 70 µg/ml.
• Note: Caution: All human source materials have tested negative for HIV1, HIV2, HBc, HCV antibodies and HBsAg by FDA approved tests. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
• Storage: Store the antigen at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_000925
• Locus ID: 5345
• Cytogenetics: 17p13.3
• Synonyms: A2AP; AAP; ALPHA-2-PI; API; PLI
• Summary: 'This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]'
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Complement and coagulation cascades