BMP9 Human Protein

CAT#: AR31169PU-N

BMP9 human recombinant protein, 10 µg

Specifications

Product Data

• Species: Human
• Expression Host: CHO
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  SAGAGSHCQK TSLRVNFEDI GWDSWIIAPK EYEAYECKGG CFFPLADDVT PTKHAIVQTL VHLKFPTKVG KACCVPTKLS PISVLYKDDM GVPTLKYHYE GMSVAECGCR
• Predicted MW: 24.1 kDa
• Purity: >95% by SDS-PAGE & HPLC analysis
• Buffer: Presentation State: Purified
  State: Lyophilized purified protein
  Stabilizer: None
• Bioactivity: Biological: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.
  The expected ED50 for this effect is 0.5-1.9 ng/ml.
• Endotoxin: < 0.1 ng per μg of GDF-2
• Reconstitution: We recommended a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/ml.
  This solution can be diluted into other aqueous buffers and stored at 4°C for one week or at –20°C for future use.
• Preparation: Lyophilized purified protein
• Protein Description: Recombinant human GDF-2 is a 24.1 kDa disulfide linked homodimeric protein consisting of two 110 amino acid polypeptide chains.
• Note: Centrifuge vials before opening!
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.

Reference Data

• RefSeq: NP_057288
• Locus ID: 2658
• UniProt ID: Q9UK05, B2RC63
• Cytogenetics: 10q11.22
• Synonyms: BMP-9; BMP9; HHT5
• Summary: 'This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jul 2016]'
• Protein Families: Druggable Genome, Secreted Protein