Thrombopoietin (22-353, His-tag)

CAT#: AR51877PU-N

Recombinant human THPO, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: Other
• Tag: His-tag
• Predicted MW: 36.5 kDa
• Concentration: 0.25 mg/ml (determined by Bradford assay)
• Buffer: Phosphate buffered saline (pH 7.4) containing 10% glycerol.
• Endotoxin: < 1.0 Eu per 1 microgram of protein (determined by LAL method)
• Preparation: Liquid purified protein

Reference Data

• RefSeq: NP_000451
• Locus ID: 7066
• Cytogenetics: 3q27.1
• Synonyms: MGDF; MKCSF; ML; MPLLG; THCYT1; TPO
• Summary: Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Hematopoietic cell lineage