Cardiac Troponin I (TNNI3) (NM_000363) Human Recombinant Protein
CAT#: TP314740
Recombinant protein of human troponin I type 3 (cardiac) (TNNI3)
View other "TNNI3" proteins (4)
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
Recombinant protein was produced with TrueORF clone, RC214740. Click on the TrueORF clone link to view cDNA and protein sequences.
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Tag | C-Myc/DDK |
Predicted MW | 23.8 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_000354 |
Locus ID | 7137 |
UniProt ID | P19429, Q6FGX2 |
Cytogenetics | 19q13.42 |
Refseq Size | 2073 |
Refseq ORF | 630 |
Synonyms | CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1 |
Summary | 'Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020]' |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency |
Protein Pathways | Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM) |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC424766 | TNNI3 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 187.00 |
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LY424766 | Transient overexpression lysate of troponin I type 3 (cardiac) (TNNI3) |
USD 605.00 |
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PH314740 | TNNI3 MS Standard C13 and N15-labeled recombinant protein (NP_000354) |
USD 2,055.00 |
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TP710224 | Purified recombinant protein of Human troponin I type 3 (cardiac) (TNNI3), full length, with C-terminal DDK tag, expressed in sf9, 20ug |
USD 425.00 |
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