SIVA (SIVA1) (NM_006427) Human Recombinant Protein

CAT#: TP315680

Recombinant protein of human SIVA1, apoptosis-inducing factor (SIVA1), transcript variant 1

Product Images

Coomassie blue staining of purified SIVA1 protein (Cat# TP315680). The protein was produced from HEK293T cells transfected with SIVA1 cDNA clone (Cat# RC215680) using MegaTran 2.0 (Cat# TT210002).

Specifications

Product Data

• Species: Human
• Expression Host: HEK293T
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Recombinant protein was produced with TrueORF clone, RC215680. Click on the TrueORF clone link to view cDNA and protein sequences.
• Tag: C-Myc/DDK
• Predicted MW: 18.5 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_006418
• Locus ID: 10572
• UniProt ID: O15304
• Cytogenetics: 14q32.33
• Refseq Size: 751
• Refseq ORF: 525
• Synonyms: CD27BP; SIVA; Siva-1; Siva-2
• Summary: This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]
• Protein Families: Druggable Genome