Shugoshin (SGO1) (NM_001012413) Human Recombinant Protein
CAT#: TP316188
Recombinant protein of human shugoshin-like 1 (S. pombe) (SGOL1), transcript variant C1
View other "SGO1" proteins (13)
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
Recombinant protein was produced with TrueORF clone, RC216188. Click on the TrueORF clone link to view cDNA and protein sequences.
|
Tag | C-Myc/DDK |
Predicted MW | 29.3 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_001012413 |
Locus ID | 151648 |
UniProt ID | Q5FBB7 |
Cytogenetics | 3p24.3 |
Refseq Size | 1149 |
Refseq ORF | 774 |
Synonyms | CAID; NY-BR-85; SGO; SGOL1 |
Summary | The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015] |
Protein Pathways | Oocyte meiosis |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC408583 | SGOL1 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC422848 | SGOL1 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 187.00 |
|
LC422849 | SGOL1 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC422850 | SGOL1 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC422851 | SGOL1 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LY408583 | Transient overexpression lysate of shugoshin-like 1 (S. pombe) (SGOL1), transcript variant C2 |
USD 396.00 |
|
LY422848 | Transient overexpression lysate of shugoshin-like 1 (S. pombe) (SGOL1), transcript variant A2 |
USD 605.00 |
|
LY422849 | Transient overexpression lysate of shugoshin-like 1 (S. pombe) (SGOL1), transcript variant B1 |
USD 396.00 |
|
LY422850 | Transient overexpression lysate of shugoshin-like 1 (S. pombe) (SGOL1), transcript variant B2 |
USD 396.00 |
|
LY422851 | Transient overexpression lysate of shugoshin-like 1 (S. pombe) (SGOL1), transcript variant C1 |
USD 396.00 |
|
PH313965 | SGOL1 MS Standard C13 and N15-labeled recombinant protein (NP_001012411) |
USD 2,055.00 |
|
PH316188 | SGOL1 MS Standard C13 and N15-labeled recombinant protein (NP_001012413) |
USD 2,055.00 |
|
TP313965 | Recombinant protein of human shugoshin-like 1 (S. pombe) (SGOL1), transcript variant B1 |
USD 788.00 |
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