Bcl2 Binding component 3 (BBC3) (NM_001127240) Human Recombinant Protein

CAT#: TP325345

Recombinant protein of human BCL2 binding component 3 (BBC3), transcript variant 1

Product Images

Coomassie blue staining of purified BBC3 protein (Cat# TP325345). The protein was produced from HEK293T cells transfected with BBC3 cDNA clone (Cat# RC225345) using MegaTran 2.0 (Cat# TT210002).

Specifications

Product Data

• Species: Human
• Expression Host: HEK293T
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Recombinant protein was produced with TrueORF clone, RC225345. Click on the TrueORF clone link to view cDNA and protein sequences.
• Tag: C-Myc/DDK
• Predicted MW: 26.3 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_001120712
• Locus ID: 27113
• UniProt ID: Q9BXH1, Q96PG8
• Cytogenetics: 19q13.32
• Refseq ORF: 783
• Synonyms: JFY-1; JFY1; PUMA
• Summary: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
• Protein Families: Druggable Genome
• Protein Pathways: Huntington's disease, p53 signaling pathway