SETDB1 (NM_001145415) Human Recombinant Protein

CAT#: TP326620

Recombinant protein of human SET domain, bifurcated 1 (SETDB1), transcript variant 1

Product Images

Coomassie blue staining of purified SETDB1 protein (Cat# TP326620). The protein was produced from HEK293T cells transfected with SETDB1 cDNA clone (Cat# RC226620) using MegaTran 2.0 (Cat# TT210002).

Specifications

Product Data

• Species: Human
• Expression Host: HEK293T
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Recombinant protein was produced with TrueORF clone, RC226620. Click on the TrueORF clone link to view cDNA and protein sequences.
• Tag: C-Myc/DDK
• Predicted MW: 143 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
• Bioactivity: Enzyme substrate (PMID: 29153392)
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_001138887
• Locus ID: 9869
• UniProt ID: Q15047
• Cytogenetics: 1q21.3
• Refseq ORF: 3873
• Synonyms: ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21
• Summary: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jun 2011]
• Protein Families: Druggable Genome
• Protein Pathways: Lysine degradation