FHIT (NM_001166243) Human Recombinant Protein

CAT#: TP328740

Recombinant protein of human fragile histidine triad gene (FHIT), transcript variant 2.

Product Images

Coomassie blue staining of purified FHIT protein (Cat# TP328740). The protein was produced from HEK293T cells transfected with FHIT cDNA clone (Cat# RC228740) using MegaTran 2.0 (Cat# TT210002).

Specifications

Product Data

• Species: Human
• Expression Host: HEK293T
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Recombinant protein was produced with TrueORF clone, RC228740. Click on the TrueORF clone link to view cDNA and protein sequences.
• Tag: C-Myc/DDK
• Predicted MW: 16.7 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
• Preparation: NULL or Add: Recombinant proteins was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_001159715
• Locus ID: 2272
• UniProt ID: P49789, A0A024R366
• Cytogenetics: 3p14.2
• Refseq Size: 1122
• Refseq ORF: 441
• Synonyms: AP3Aase; FRA3B
• Summary: 'The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]'
• Protein Pathways: Non-small cell lung cancer, Purine metabolism, Small cell lung cancer