TIE1 (NM_005424) Human Recombinant Protein

CAT#: TP700156

Purified Recombinant protein of human tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE1), with C-terminal DDK/His tag, expressed in human cells, 20 µg

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence from TrueORF clone, RC600056, encoding the region (Ala22 – Gln759) of human TIE1
• Tag: C-DDK/His
• Predicted MW: 82.6 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: PBS, pH7.4, 10% glycerol
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_005415
• Locus ID: 7075
• UniProt ID: P35590
• Cytogenetics: 1p34.2
• Refseq Size: 4000
• Refseq ORF: 2277
• Synonyms: JTK14; TIE
• Summary: This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane