RYK (NM_001005861) Human Recombinant Protein

CAT#: TP700167

Purified recombinant protein of human receptor-like tyrosine kinase (RYK), transcript variant 1, with C-terminal DDK/His tag, expressed in human cells, 20 µg


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USD 748.00

2 Weeks*

Size
    • 20 ug

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Specifications

Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC600067, encoding the region (Pro26 – Arg224) of human RYK
Tag C-DDK/His
Predicted MW 25 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer PBS, pH7.4, 10% glycerol
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_001005861
Locus ID 6259
UniProt ID P34925, Q8WTZ8, Q59FQ5
Cytogenetics 3q22.2
Refseq Size 2942
Refseq ORF 678
Synonyms D3S3195; JTK5; JTK5A; RYK1
Summary The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Protein Families Druggable Genome, Protein Kinase, Transmembrane

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.