APE1 (APEX1) (NM_001641) Human Recombinant Protein

CAT#: TP720082

Recombinant protein of human APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1


  View other "APE1" proteins (13)

USD 330.00

3 Weeks*

Size
    • 10 ug

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Frequently bought together (1)
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    • 100 ul

USD 379.00

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Tag tag free
Predicted MW 35.6 kDa
Concentration lot specific
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Supplied as a 0.2 um filtered solution of 10mM HEPES, 100mM KCl, 50% Glycerol, pH 7.4.
Bioactivity Co-immunoprecipitation (PMID: 27808278)
Endotoxin < 0.1 EU per µg protein as determined by LAL test
Storage Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Stability Stable for at least 3 months from date of receipt under proper storage and handling conditions.
Reference Data
RefSeq NP_001632
Locus ID 328
UniProt ID P27695, Q5TZP7
Cytogenetics 14q11.2
Synonyms APE; APE1; APEN; APEX; APX; HAP1; REF1
Summary The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases.[provided by RefSeq, Dec 2019]
Protein Families Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways Base excision repair

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.