LBP (NM_004139) Human Recombinant Protein

CAT#: TP720319L

Recombinant protein of human lipopolysaccharide binding protein (LBP)

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Ala26-Val481
• Tag: C-His
• Predicted MW: 51.9 kDa
• Concentration: lot specific
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Lyophilized from a 0.2 um filtered solution of 20mM Tris-HCl,500mM NaCl,1mM EDTA,pH 8.0.
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Reference Data

• RefSeq: NP_004130
• Locus ID: 3929
• UniProt ID: P18428, Q8TCF0
• Cytogenetics: 20q11.23
• Synonyms: BPIFD2
• Summary: The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Toll-like receptor signaling pathway