Cathepsin L (CTSL) (NM_001912) Human Recombinant Protein

CAT#: TP720657

Purified recombinant protein of Human cathepsin L1 (CTSL1), transcript variant 1


  View other "Cathepsin L" proteins (8)

USD 330.00

3 Weeks*

Size
    • 10 ug

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Frequently bought together (1)
CTSL1 mouse monoclonal antibody,clone OTI2H2
    • 100 ul

USD 379.00

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Specifications

Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Tag C-His
Predicted MW 36.88 kDa
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Supplied as a 0.2 um filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.5.
Endotoxin Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Storage Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Stability Stable for at least 3 months from date of receipt under proper storage and handling conditions.
Reference Data
RefSeq NP_001903
Locus ID 1514
UniProt ID P07711, A0A024R276
Cytogenetics 9q21.33
Refseq Size 1730
Refseq ORF 999
Synonyms CATL; CTSL1; MEP
Summary The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020]
Protein Families Druggable Genome, Protease
Protein Pathways Antigen processing and presentation, Lysosome

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.