TPP1 (NM_000391) Human Recombinant Protein

CAT#: TP721045

Purified recombinant protein of Human tripeptidyl peptidase I (TPP1)

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Ser20-Pro563
• Tag: C-His
• Predicted MW: 23.94 kDa
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM CaCl2, 10% Glycerol, pH 7.5.
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
• Storage: Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
• Stability: Stable for at least 3 months from date of receipt under proper storage and handling conditions.

Reference Data

• RefSeq: NP_000382
• Locus ID: 1200
• UniProt ID: O14773
• Cytogenetics: 11p15.4
• Refseq Size: 3540
• Refseq ORF: 1689
• Synonyms: CLN2; GIG1; LPIC; SCAR7; TPP-1
• Summary: This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]
• Protein Families: Protease
• Protein Pathways: Lysosome