IL1 alpha (IL1A) (NM_000575) Human Recombinant Protein

CAT#: TP723707

Purified recombinant protein of Human interleukin 1, alpha (IL1A)

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Human IL-1alpha;, the region of Ser113-Ala271, from gene Accession# NM_000575
• Tag: Tag Free
• Predicted MW: 18 Da
• Concentration: Protein formulated and vialed at >50 ug/mL in specified buffer
• Purity: Purity is >98%, as determined by Coomassie stained SDS-PAGE.
• Buffer: 10mM NaH2PO4, 150mM NaCl, pH7.2
• Bioactivity: The ED50 is 5 - 15 pg/ml, corresponding to a specific activity of 0.6-2.0 x 10^7 units/mg, determined by the dose dependent stimulation of D10 cells proliferation.
• Endotoxin: Less than 0.01 ng per ug protein as determined by the LAL method
• Storage: Store at -80°C.
• Stability: Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.

Reference Data

• RefSeq: NP_000566
• Locus ID: 3552
• UniProt ID: P01583
• Cytogenetics: 2q14.1
• Refseq Size: 2943
• Refseq ORF: 813
• Synonyms: IL-1 alpha; IL-1A; IL1; IL1-ALPHA; IL1F1
• Summary: 'The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]'
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, Prion diseases, Type I diabetes mellitus