Fas Ligand (FASLG) (NM_000639) Human Recombinant Protein

CAT#: TP723853

Purified recombinant protein of Human Fas ligand (TNF superfamily, member 6) (FASLG / TNFSF6)

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: CHO
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Human FASL, the region of N-Met-His8 (Pro134-Leu281), from gene Accession# NM_000639.1
• Tag: Tag Free
• Predicted MW: 18 kDa
• Concentration: Protein formulated and vialed at >50 ug/mL in specified buffer
• Purity: >90%, as determined by Coomassie stained SDS-PAGE.
• Buffer: 1 x PBS
• Bioactivity: The ED50 is 1.5 - 6 ng/ml, corresponding to a specific activity of 1.6 - 6.6 x 10^5 units/mg, determined by the dose dependent stimulation of Jurkat death cell induced by apoptosis.
• Endotoxin: Less than 0.01 ng per µg protein as determined by the LAL method
• Storage: Store at -80°C.
• Stability: Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.

Reference Data

• RefSeq: NP_000630
• Locus ID: 356
• UniProt ID: P48023, Q53ZZ1
• Cytogenetics: 1q24.3
• Refseq Size: 1909
• Refseq ORF: 843
• Synonyms: ALPS1B; APT1LG1; APTL; CD95-L; CD95L; CD178; FASL; TNFSF6; TNLG1A
• Summary: 'This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]'
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Allograft rejection, Apoptosis, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Pathways in cancer, Type I diabetes mellitus