TGF alpha (TGFA) (NM_003236) Human Recombinant Protein

CAT#: TP723858

Purified recombinant protein of Human transforming growth factor, alpha (TGFA), transcript variant 1

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Human TGF-alpha;, the region of Val40-Ala89, from gene Accession# NM_003236
• Tag: Tag Free
• Predicted MW: 5.5 kDa
• Concentration: Protein formulated and vialed at >50 ug/mL in specified buffer
• Purity: >98%, as determined by Coomassie stained SDS-PAGE.
• Buffer: 1 x PBS
• Bioactivity: The ED50 is 0.1 - 0.4 ng/ml, corresponding to a specific activity of 0.25 - 1.0 x 10^7 units/mg, determined by the dose dependent stimulation of BALB/c-3T3 mouse embryonic fibroblast cells proliferation.
• Endotoxin: Less than 0.01 ng per µg protein as determined by the LAL method
• Storage: Store at -80°C.
• Stability: Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.

Reference Data

• RefSeq: NP_003227
• Locus ID: 7039
• UniProt ID: P01135
• Cytogenetics: 2p13.3
• Refseq Size: 4326
• Refseq ORF: 507
• Synonyms: TFGA
• Summary: This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: ErbB signaling pathway, Glioma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Renal cell carcinoma