Porimin (TMEM123) (NM_052932) Human Recombinant Protein

CAT#: TP761936

Purified recombinant protein of Human transmembrane protein 123 (TMEM123),full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug


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USD 215.00

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Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding human full length of TMEM123
Tag N-GST, C-His
Predicted MW 47 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0,150 mM NaCl, 10% glycerol,1%Sarkosyl
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_443164
Locus ID 114908
UniProt ID Q8N131
Cytogenetics 11q22.2
Refseq Size 3605
Refseq ORF 624
Synonyms KCT3; PORIMIN; PORMIN
Summary This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]
Protein Families Transmembrane

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