BCL2 (NM_000633) Human Recombinant Protein

CAT#: TP762352

Purified recombinant protein of Human B-cell CLL/lymphoma 2 (BCL2), nuclear gene encoding mitochondrial protein, transcript variant alpha, Gly54-Val66(8 reapeat regions linked with GGGGS), with N-terminal His tag, expressed in E.coli, 50ug

Product Images

Purified recombinant protein BCL2 was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  GHTPHPAASR DPVGGGGSGH TPHPAASRDP VGGGGSGHTP HPAASRDPVG GGGSGHTPHP
  AASRDPVGGG GSGHTPHPAA SRDPVGGGGS GHTPHPAASR DPVGGGGSGH TPHPAASRDP
  VGGGGSGHTP HPAASRDPV
• Tag: N-His
• Predicted MW: 12.8 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_000624
• Locus ID: 596
• UniProt ID: P10415, A0A024R2B3
• Cytogenetics: 18q21.33
• Refseq Size: 6492
• Refseq ORF: 717
• Synonyms: Bcl-2; PPP1R50
• Summary: 'This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]'
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency, Transmembrane
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Focal adhesion, Neurotrophin signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer