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Posts for 2018
2018 Nobel Prize in Medicine Awarded to 2 Immunotherapy Researchers
Oct 23, 2018
The 2018 Noble Prize in Physiology or Medicine was awarded on Monday, October 1st, 2018 to Tasuku Honjo of Japan and James P. Allison of the United States for discovering Immuno Oncology Checkpoint Proteins (I-O) that have fundamentally changed the way some cancers are treated. Unlike previous cancer therapies that target cancer cells directly, their discovery targets the “brakes” of the host immune system. Role...
To be, or not to be, that is the question.
Oct 02, 2018
As your gene company, OriGene wants to offer you, the molecular biologists, a complete solution: not just expression-ready clones, but also transfection-ready purified plasmid DNA. For a limited time, we are offering 20,000 mouse expression clones for $48 per vial of 10ug plasmid DNA. With this, you will skip the tedious work of transformation / E. coli culture / plasmid prep / sequence verification /...
MAGEA4 is Hot Right Now!
Jul 16, 2018
What makes MAGEA4 a hot target? Melanoma Antigen Gene (MAGE) type A4 acts as an activator of Trans-lesion synthesis, an error-prone mechanism for DNA repair. Interest in the antigen began when the MAGE proteins were found to only express in the testes, placenta, and several types of tumors. This differentiation made MAGEA4 a perfect immunotherapeutic target, and the excitement in the research community ignited. A...
Biosafety considerations when handling lentivirus
Jun 14, 2018
Human ingenuity has turned the sinister HIV-1 virus into a convenient laboratory tool for gene delivery as lentiviral vector. After multiple rounds of engineering, the 3rd generation of lenti viral system has diminished the possibility for the lab-made virus to replicate and to impose health risk to laboratory staff. While it is important that we treat all laboratory tools with respect, there is no reason...
Antibody Validation – How do we confirm the specificity of an antibody?
May 12, 2018
One common question that scientists always ask when they get the signal from an antibody based assay is: "Does this signal truly represent the presence and quantity of my protein?" Antibody specificity is always a concern for scientists. Even though there are a number of validation methods that have been used for the specificity testing, the data is often over-interpreted. Research data from various groups...