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Human IL6: A Pleiotropic Inflammatory Cytokine
Jul 11, 2022
Interleukin 6?(IL-6)?is a pleiotropic cytokine. It plays important role in inflammation disorders, autoimmune diseases, obesity, and cancer. Levels of?IL-6?in human blood are very low under normal conditions, but the levels can increase thousands-fold in inflammatory states. Thus, monitoring IL-6 levels can help in diagnosing and preventing infectious diseases.
IL-6 Signaling Pathway
IL-6?has both pro-and anti-inflammatory functions that are mediated by the soluble form of IL-6 receptor (sIL-6R; trans-signaling) and the membrane-bound?IL-6R?(classic signaling). Ligand-bound?IL-6?receptors can assemble with the integral protein gp130 (IL6ST) to recruit non-receptor tyrosine kinases (e.g.,?JAK1) and activate?STAT3.
IL-6 Resource Tool Center
Assay Kits for IL6
OriGene's?IL6 ELISA kit?provides sensitive and reliable?IL-6?measurements to obtain valuable data from your experiments.
Get your IL-6 Elisa Kit here
Antibodies for IL6
OriGene has developed highly-specific and sensitive antibodies that recognize native epitopes which can be used in IHC, ELISA, WB. IF, IP etc
Primary Antibodies
IHC staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-IL-6 mouse monoclonal antibody.
Carrier-Free Antibodies
IHC staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-IL-6 mouse monoclonal antibody.
Primary Antibody Samples
IHC staining of paraffin-embedded Human prostate tissue within the normal limits using anti-IL-6 mouse monoclonal antibody.
Clones for IL6
OriGene has developed expression ready plasmids and Lentiviral particles for various species such as human, mouse and rat species.
Tagged/Un-Tagged Clones
HEK293T cells were transfected with the pCMV6-ENTRY control (Cat#?PS100001, Left lane) or pCMV6-ENTRY IL-6 (Cat# RC202078, Right lane) cDNA for 48 hrs and lysed
Lentiviral Particles
HEK293T cells were transduced with RC202078L4V particle to overexpress human IL6-mGFP fusion protein.