ST2: Potential Biomarker For Cardiovascular Disease

Oct 21, 2024

The ST2 gene (also known as IL1RL1) is a potential biomarker of poor prognosis in cardiovascular diseases. ST2 is present in two important isoforms: Membrane-bound ST2 (ST2L) and soluble ST2 (sST2). ST2L binds with IL33 and has a cardioprotective effect like decreased cardiac damage, prevention of apoptosis, lowered inflammatory effect, hypertrophy, and fibrosis. However, the binding of sST2 to IL33 causes the protective effect to disappear.

Elevated levels of soluble ST2 are seen in the pericardial fluid and plasma of patients with coronary artery disease. Analyzing soluble ST2 levels in other cardiovascular diseases can strengthen its potential to be used as a biomarker¹

Fig 1:Cardioprotective relation of IL33 with ST2 and sST2

Products for ST2 research

ELISA Kits

OriGene has developed a highly- specific and sensitive ELISA Kit for quantitatively detecting ST2 levels in human serum, plasma, and other biological fluids.

Sensitivity: 5.9 pg/ml

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