SFTPB Mouse Monoclonal Antibody [Clone ID: 1B9]
Other products for "PMS2"
Specifications
Product Data | |
Clone Name | 1B9 |
Applications | IF, IHC |
Recommended Dilution | Immunofluorescence. Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/100 Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended. Use Polymer anti Mouse/Rabbit IgG as a detection system. Positive Control: Lung adenocarcinoma. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | Recombinant Surfactant Protein B. |
Specificity | This antibody detects Surfactant Protein B (Mature). Cellular Localization: Cytoplasmic. |
Formulation | State: Supernatant State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide. |
Storage | Store the antibody undiluted at 2-8°C. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens PMS1 homolog 2, mismatch repair system component (PMS2), transcript variant 1 |
Database Link | |
Background | ProSP-B is glycosylated in the Golgi apparatus and undergoes carboxy- and amino-terminal proteolysis by a cathepsin D-like protease. Pulmonary surfactant is a complex mixture of phospholipids and proteins that is secreted from type II cells in alveoli and reduces the surface tension at the alveolar air-liquid interface, providing alveolar stability necessary for normal ventillation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP-A (28-36kDa) and SP-D (43kDa) are collagenous carbohydrate-binding proteins, whereas SP-B (8-9kDa) and SP-C (4kDa) are non-collagenous hydrophobic proteins. SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. |
Synonyms | Surfactant protein B, SP-B, SFTP3 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Mismatch repair |
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