SFTPB Mouse Monoclonal Antibody [Clone ID: 1B9]

CAT#: AM00341SU-N

SFTPB mouse monoclonal antibody, clone 1B9, Supernatant

Product Images

Formalin-Fixed, Paraffin-Embedded Human lung stained with Surfactant antibody Cat.-No. AM00341SU-N using peroxidase conjugate and DAB chromogen. Note the cytoplasmic staining of type II pneumocytes.

Specifications

Product Data

• Clone Name: 1B9
• Applications: IF, IHC
• Recommended Dilution: Immunofluorescence.
  Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/100
  Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended.
  Use Polymer anti Mouse/Rabbit IgG as a detection system.
  Positive Control: Lung adenocarcinoma.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant Surfactant Protein B.
• Specificity: This antibody detects Surfactant Protein B (Mature).
  Cellular Localization: Cytoplasmic.
• Formulation: State: Supernatant
  State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens PMS1 homolog 2, mismatch repair system component (PMS2), transcript variant 1
• Database Link:
  Entrez Gene 5395 HumanEntrez Gene 6439 Human
• Background: ProSP-B is glycosylated in the Golgi apparatus and undergoes carboxy- and amino-terminal proteolysis by a cathepsin D-like protease. Pulmonary surfactant is a complex mixture of phospholipids and proteins that is secreted from type II cells in alveoli and reduces the surface tension at the alveolar air-liquid interface, providing alveolar stability necessary for normal ventillation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP-A (28-36kDa) and SP-D (43kDa) are collagenous carbohydrate-binding proteins, whereas SP-B (8-9kDa) and SP-C (4kDa) are non-collagenous hydrophobic proteins. SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B.
• Synonyms: Surfactant protein B, SP-B, SFTP3

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Mismatch repair