Wilms Tumor Protein (WT1) Mouse Monoclonal Antibody [Clone ID: 6F-H2]

CAT#: AM00403SU-L

Wilms Tumor Protein (WT1) mouse monoclonal antibody, clone 6F-H2, Supernatant

Product Images

Formalin-Fixed, Paraffin-Embedded Human Wilms tumor stained with WT1 antibody Cat.-No. AM00403SU-L using peroxidase conjugate and DAB chromogen. Note the nuclear staining of tumor cells.

Specifications

Product Data

• Clone Name: 6F-H2
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/10-1/50
  Pretreatment of tissue with proteolytic enzymes should be performed prior to staining.
  Use Polymer anti Mouse/Rabbit IgG as a detection system.
  Positive Control: Malignant mesothelioma, Wilms tumor.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified WT protein.
• Specificity: This antibody recognizes Wilm's Tumor Protein.
  Lung adenocarcinomas rarely stain positive with this antibody.
  Cellular Localization: Nuclear.
• Formulation: State: Supernatant
  State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens PMS1 homolog 2, mismatch repair system component (PMS2), transcript variant 1
• Database Link:
  Entrez Gene 5395 HumanEntrez Gene 7490 Human
• Background: Wilm's Tumor (WT), a sporadic and familial childhood kidney tumor, is genetically heterogeneous. Wilm's tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilms tumor and mesothelioma.
• Synonyms: WT33

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Mismatch repair