ICOS Ligand (ICOSLG) Mouse Monoclonal Antibody [Clone ID: MIH11]

CAT#: AM05615FC-N

Mouse Monoclonal Anti-ICOSLG Antibody, FITC

Product Images

Figure 1. Staining of Human peripheral blood monocytes with Mouse anti Human CD275 antibody FITC conjugated

Specifications

Product Data

• Clone Name: MIH11
• Applications: FC
• Recommended Dilution: FC
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: CD275 - L cells.
  Spleen cells from immunised BALB/c mice were fused with cells of the P3U1 myeloma cell line.
• Specificity: This antibody detects CD275, also known as ICOS ligand (inducible T cell co-stimulator ligand).
  This clone MIH11 is reported to partially block the interaction between CD275 and CD278.
• Formulation: PBS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer
• Concentration: 0.1 mg/ml
• Purification: Affinity Chromatography on Protein G.
• Conjugation: FITC
• Predicted Protein Size: 33.2 kDa
• Gene Name: inducible T-cell costimulator ligand
• Database Link:
  NP_056074
  Entrez Gene 23308 Human
• Background: CD275 is a member of the B7 family, and interaction with its receptor CD278 (ICOS) plays an important role in T cell co-stimulation and inflammatory immune reactions.CD275 is expressed on activated B-cells, monocytes and dendritic cells and is also induced on non-lymphoid tissue cells such as endothelial cells, epithelial cells and muscle cells. CD275 has an important physiological role in the reactivation of effector/memory T cells on the endothelium, thus controlling entry of immune cells into inflamed tissue. The CD278-CD275 pathway is thought to be critical in the immune response to transplants, allergies and autoimmune diseases.
• Synonyms: B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; KIAA0653; LICOS

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)