AKR1C1 (1-323) Mouse Monoclonal Antibody [Clone ID: AT6D10]

CAT#: AM09389PU-N

AKR1C1 (1-323) mouse monoclonal antibody, clone AT6D10, Purified

Product Images

Western blot analysis: The extracts of HepG2 (33 ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human AKR1C1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Specifications

Product Data

• Clone Name: AT6D10
• Applications: ELISA, FC, IF, IHC, WB
• Recommended Dilution: ELISA.
  Western blot: 1/1000.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Immunocytochemistry / Immunoflourescence.
  Flow cytometry.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human AKR1C1 (1-323aa) purified from E. coli
• Specificity: The antibody recognizes Human AKR1C1 at aa 1-323.
• Formulation: PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein G
• Storage: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens aldo-keto reductase family 1, member C1 (AKR1C1)
• Database Link:
  Entrez Gene 1645 Human
• Background: The human aldo-keto reductases 1C1 and 1C3 (AKR1C1 and AKR1C3) have major roles in pre receptor regulation of progesterone action. They can both convert progesterone to the less potent efficiencies. AKR1C1 and AKR1C3 also act as 3-ketosteroid reductase, and as such they can convert the most potent androgen 5alpha-DHT into 3beta-andorstandiol, which is an estrogen receptor beta ligand, and into the inactive androgen 3alpha-androstnionl, respectively.
• Synonyms: 20-alpha-hydroxysteroid dehydrogenase

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolism of xenobiotics by cytochrome P450