beta Catenin (CTNNB1) Rabbit Monoclonal Antibody [Clone ID: E247]

CAT#: AM10048SU-N

beta Catenin (CTNNB1) rabbit monoclonal antibody, clone E247, Supernatant

Product Images

Formalin-Fixed, Paraffin-Embedded Human mesenteric fibromatosis stained with Beta-Catenin antibody Cat.-No. AM10048SU-N using peroxidase conjugate and DAB chromogen. Note nuclear staining of tumor cells.

Specifications

Product Data

• Clone Name: E247
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/100
  Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended.
  Use Polymer anti Mouse/Rabbit IgG as a detection system.
  Positive Control: Fibromatosis, transitional cell carcinoma.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues near N-terminus of human beta-Catenin.
• Specificity: Recognizes Beta-Catenin.
  Cellular Localization: Cytoplasmic and nuclear.
• Formulation: State: Supernatant
  State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Mus musculus forkhead box P3 (Foxp3), transcript variant 1
• Database Link:
  Entrez Gene 50943 HumanEntrez Gene 1499 Human
• Background: Beta-Catenin is a 92 kD protein normally found in the cytoplasm of the cell in the submembranous location. This protein is associated with E-Cadherin and may be essential for the function of E-Cadherin. Mutations in the Beta-Catenin gene result in loss of membranous staining and nuclear accumulation of this protein. Nuclear accumulation of this protein has been demonstrated in Desmoid-type Fibromatosis lesions of the breast and abdomen and therefore is useful in differentiating this lesion from other spindle cell lesions that may occur in these locations. Nuclear accumulation of Beta-Catenin has also been demonstrated in colorectal carcinoma.
• Synonyms: CTNNB1, CTNNB, Beta-catenin