Factor VIII (F8) Mouse Monoclonal Antibody [Clone ID: F8 2.2.9]

CAT#: AM20504PU-N

Factor VIII (F8) mouse monoclonal antibody, clone F8 2.2.9, Purified


USD 440.00

2 Weeks*

Size
    • 50 ug

Product Images

Specifications

Product Data
Clone Name F8 2.2.9
Applications IHC
Recommended Dilution Immunohistochemistry on Paraffin Sections: 10 µg/ml.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen F8 antibody was raised against purified human Factor VIII.
Specificity This antibody recognizes full-length Human Factor VIII (F8). Does not cross-react with von Willebrand factor.
Formulation PBS, pH 7.4
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Protein G chromatography
Storage Upon receipt, store (in aliquots) at -20°C to -80°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens coagulation factor VIII (F8), transcript variant 1
Background This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Synonyms Procoagulant component, Antihemophilic factor, F8C, AHF
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Complement and coagulation cascades

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.