alpha 1 Antichymotrypsin (SERPINA3) Mouse Monoclonal Antibody [Clone ID: n.a]

CAT#: AM20848PU-N

alpha 1 Antichymotrypsin (SERPINA3) mouse monoclonal antibody, clone n.a, Aff - Purified

Specifications

Product Data

• Clone Name: n.a
• Applications: ELISA
• Recommended Dilution: ELISA.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human anti-Chymotrypsin (ACT)
• Specificity: This antibody recognizes Alpha-1-antichymotrypsin (ACT).
• Formulation: State: Aff - Purified
  State: Liquid purified Ig fraction
• Purification: Protein A or Protein G Affinity Chromatography. Elution with 5 mM Citric Acid pH 2.5, neutralization with 50 mM Na2HPO4 at pH 8.8.
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 (SERPINA3)
• Database Link:
  Entrez Gene 12 Human
• Background: Chymotrypsins, such as Chymotrypsin C (also known as pancreatic Chymotrypsin or Chymotrypsin), are digestive enzymes that can perform proteolysis by cleaving peptides at the carboxyl side of tyrosine, tryptophan and phenylalanine, although over time they can also hydrolyze other amide bonds, especially those with leucine-donated carboxyls. Chymotrypsins cleave peptide bonds by attacking the un-reactive carbonyl group with a powerful nucleophile, the Serine 195 residue located in the active site of the enzyme, which momentarily becomes covalently bonded to the substrate to form an intermediate. Chymotrypsin C is synthesized in the pancreas by protein biosynthesis as a precursor called chymotrypsinogen that is enzymatically inactive, but becomes active as a three polypeptide molecule that is interconnected by disulfide bonds.
• Synonyms: SERPINA3, AACT, GIG24, GIG25

Reference Data

• Protein Families: Druggable Genome, Secreted Protein