MICA Mouse Monoclonal Antibody [Clone ID: B-N31]

CAT#: AM31271AF-N

MICA mouse monoclonal antibody, clone B-N31, Azide Free

Specifications

Product Data

• Clone Name: B-N31
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human MICA
• Specificity: This antibody recognises both natural and recombinant MICA.
• Formulation: Phosphate-buffered saline.
  Sterile-filtered through 0.22 µm.
  Carrier and preservative free
  State: Azide Free
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Ion Exchange Chromatography
• Gene Name: Homo sapiens MHC class I polypeptide-related sequence A (MICA), transcript variant 1*001
• Database Link:
  Entrez Gene 100507436 Human
• Background: The MHC class I chain-related (MIC) proteins are related to the Major histocompatibility complex (MHC) class I proteins which are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. The MHC class I chain-related (MIC) proteins are recognized by NKG2D, a receptor on NK and T cells, and promote antitumor activity. MICA, a member of the MIC family, is widely expressed on many tumors, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes.
  MICA is present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system. MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells.
• Synonyms: MHC class I polypeptide-related sequence A, MIC-A, PERB11.1