ATF6 Mouse Monoclonal Antibody [Clone ID: 3D5]

CAT#: AM31749PU-N

ATF6 mouse monoclonal antibody, clone 3D5, Purified

Product Images

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 3D5
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: ATF6 antibody was raised against ATF6 (AAH14969, 91 a.a. ~ 194 a.a) partial recombinant protein with GST tag.
• Specificity: Recognizes ATF6
• Formulation: PBS, pH 7.2
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 0.36 mg/ml
• Purification: Protein A Chromatography
• Gene Name: Homo sapiens activating transcription factor 6 (ATF6)
• Database Link:
  Entrez Gene 22926 Human
• Background: Activating Transcription Factor 6 (ATF6) is a type II transmembrane glycoprotein located on the ER membrane. In response to ER stress ATF6 is cleaved and the N-terminus including the leucine zipper (which faces the cytosol) moves to the nucleus. Once in the nucleus ATF6 binds to the ER stress response elements in ER stress genes. Site-1 and site-2 protease enzymes that process sterol regulatory binding proteins in response to cholesterol derivation cleave ATF6.
• Synonyms: ATF-6, Activating transcription factor 6 alpha

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Alzheimer's disease