STK38 (365-466) Mouse Monoclonal Antibody [Clone ID: 6F1]

CAT#: AM31888PU-N

STK38 (365-466) mouse monoclonal antibody, clone 6F1, Purified

Product Images

Western Blot analysis of STK38 expression in PC-12 using STK38 antibody.

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  Western Blot analysis of STK38 expression in HeLa NE using STK38 antibody.

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  Western Blot analysis of STK38 expression in NIH/3T3 using STK38 antibody.

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  Detection limit for recombinant GST tagged STK38 is approximately 0.1 ng/ml as a capture antibody.

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  Formalin-Fixed, Paraffin-Embedded Human Testis stained with STK38 Antibody at 1 ug/ml tissue after heat-induced antigen retrieval.

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Specifications

Product Data

• Clone Name: 6F1
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 1 - 10 µg/ml.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: STK38 (AAH12085, 365 a.a. ~ 466 a.a) partial recombinant protein with GST tag
• Specificity: Recognizes STK38 at aa 365-466.
• Formulation: PBS, pH 7.4
  State: Purified
  State: Liquid purified IgG fraction
• Concentration: 0.31 mg/ml
• Purification: Protein A Chromatography
• Gene Name: Homo sapiens serine/threonine kinase 38 (STK38), transcript variant 1
• Database Link:
  Entrez Gene 106504 MouseEntrez Gene 361813 RatEntrez Gene 11329 Human
• Background: STK38 contains 1 protein kinase domain that interacts with mob1 and mob2.The homodimeric s100b binds to two molecules of stk38. It is ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Stk38 activated by binding of s100b which releases autoinhibitory n-lobe interactions, enabling atp to bind and the autophosphorylation of ser-281. thr-444 then undergoes calcium- dependent phosphorylation by an upstream kinase. Interactions between phosphorylated thr-444 and the n-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of mob1/mobkl1a and mob2/hcca2 to the n-terminal of stk38.
• Synonyms: Serine/threonine-protein kinase 38, NDR1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase