MAP4K1 Mouse Monoclonal Antibody [Clone ID: 2A1]

CAT#: AM31910SU-N

MAP4K1 mouse monoclonal antibody, clone 2A1, Purified

Product Images

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 2A1
• Applications: IHC, IP, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 1/200.
  Immunoprecipitation.
  Western Blot: 1/5000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human protein purified from E. coli (His/ABD-HPK1)
• Specificity: Recognizes Human MAP4K1.
• Formulation: HEPES with 0.15M NaCl, 0.01% BSA, 0.03% Sodium Azide and 50% Glycerol
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 2 mg/ml
• Purification: Ammonium Sulfate Precipitation
• Gene Name: Homo sapiens mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1), transcript variant 1
• Database Link:
  Entrez Gene 11184 Human
• Background: HPK1, a KHS protein kinase, is an upstream activator of the stress-activated protein kinase (SAPK) signaling pathway. The protein has a structure similar to other GCK (Group I) kinases and contains four consensus SH3 binding motifs, which have been shown to interact with the SH3 motifs of the MAP kinase kinase kinases MLK3 and MEKK1 and several adapter proteins that couple to tyrosine kinases, including BASH, Blnk, Clnk, Crk, CrkL and Grb2. Additionally, HPK1 has been shown to be phosphorylated and activated by the tyrosine kinase c-Abl in response to genotoxic agents. At least two mRNA transcripts have been reported.
• Synonyms: MEKKK 1, MAPK/ERK kinase kinase kinase 1, HPK1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: MAPK signaling pathway