GCLM Mouse Monoclonal Antibody [Clone ID: AT2D12]
Other products for "GCLM"
Specifications
Product Data | |
Clone Name | AT2D12 |
Applications | ELISA, FC, IF, WB |
Recommended Dilution | ELISA. Western blot: 1/3000 (using HeLa cells (40 µg), resolved by SDS-PAGE). Flow cytometry: 2-5 µg in 1x106 cells (in HeLa cell line). Immunofluorescence/Immnunocytochemistry: 1/100 (in HeLa cell line). |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Recombinant human GCLM (1-274aa) purified from E. coli |
Formulation | PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction |
Concentration | 1.0 mg/ml |
Purification | Protein-G affinity chromatography |
Gene Name | Homo sapiens glutamate-cysteine ligase modifier subunit (GCLM), transcript variant 1 |
Database Link | |
Background | GCLM (Glutamate-cysteine ligase, modifier subunit), also known as gamma-glutamylcysteine synthetase, is first rate limiting enzyme of glutathione synthesis. GCLM is heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. GCLM deficiency has been implicated in some forms of hemolytic anemia. Also, GCLM is a molecular target for amelioration of cisplatin restance in lung cancer. |
Synonyms | Gamma-ECS regulatory subunit, GCS light chain |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Glutathione metabolism, Metabolic pathways |
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