SIAH Interacting Protein (CACYBP) Mouse Monoclonal Antibody [Clone ID: AT3G8]

CAT#: AM50340PU-N

SIAH Interacting Protein (CACYBP) mouse monoclonal antibody, clone AT3G8, Purified

Product Images

The cell lysates of HeLa, 293T, Jurkat and A549 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CACYBP antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Specifications

Product Data

• Clone Name: AT3G8
• Applications: ELISA, WB
• Recommended Dilution: The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant human CACYBP (1-185aa) purified from E. coli.
• Formulation: PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Protein-A affinity chromatography
• Gene Name: Homo sapiens calcyclin binding protein (CACYBP), transcript variant 2
• Database Link:
  Entrez Gene 27101 Human
• Background: CACYBP (Calcyclin-binding protein) is primarily a nuclear protein that contains one CS domain and one SGS domain. CACYBP is believed to be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It most likely serves as a molecular bridge in ubiquitin E3 complexes. It also participates in the ubiquitin-mediated degradation of b-catenin. CACYBP is thought to be a potential inhibitor of cell growth and invasion in the gastric cancer cell through its effects on b-catenin protein expression and transcriptional activation of TCF/LEF.
• Synonyms: Calcyclin-binding protein, S100A6BP, SIP, PNAS-107, Siah-interacting protein, S100A6-binding protein

Reference Data

• Protein Pathways: Wnt signaling pathway