LXR beta (NR1H2) Rabbit Polyclonal Antibody

CAT#: AP00294PU-N

LXR beta (NR1H2) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of LXR expression in Jurkat cell lysate (Lane 1) and mouse small intestine tissue lysate (Lane 2).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 0.5-4 μg/ml; Jurkat cell lysate and mouse small intestine tissue lysate can be used as positive controls.
• Reactivities: Bovine, Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 435 of human LXR
• Specificity: The antibody detects 49 kDa LXR alpha and beta subunits of LXR.
• Formulation: PBS, pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01% thimerosal
  State: Aff - Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Affinity purified
• Storage: Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens nuclear receptor subfamily 1 group H member 2 (NR1H2), transcript variant 1
• Database Link:
  Entrez Gene 22260 MouseEntrez Gene 58851 RatEntrez Gene 7376 Human
• Background: Liver X receptors (LXRs) are oxysterol activated nuclear receptors which are involved in the regulation of genesis and metabolism of cholesterols and bile acids. LXRs form heterodimeric complexes with the retinoic acid receptors (RARs) once activated by their respective oxysterol ligands. Two known isoforms, alpha and beta, are differentially expressed; the alpha isoform predominantly expressed in liver, whereas beta isoform expression has been shown to be ubiquitous.
• Synonyms: LXRA, LXRB, NER, UNR

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors