LGR8 (RXFP2) Rabbit Polyclonal Antibody
Other products for "RXFP2"
Specifications
Product Data | |
Applications | IF, WB |
Recommended Dilution | Western Blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. |
Reactivities | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 120-165 of Human Relaxin Receptor 2. |
Specificity | This antibody detects endogenous levels of Relaxin Receptor 2 protein. |
Formulation | PBS, pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (>95% by SDS-PAGE) Preservative: 0.05% Sodium Azide |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography using epitope-specific immunogen |
Predicted Protein Size | ~ 86 kDa |
Gene Name | Homo sapiens relaxin/insulin-like family peptide receptor 2 (RXFP2), transcript variant 1 |
Database Link | |
Background | Relaxins are endocrine and autocrine/paracrine hormones belonging to the insulin gene superfamily. In several mammalian species, relaxin is best known for its role during pregnancy and parturition, when it is produced by the corpora lutea of ovaries and other reproductive tissues. The secretion of relaxin into the blood stream just before parturition results in a marked softening and lengthening of the pubic symphysis and a softening of the cervix, which facilitates the birth process. Also, by inhibiting uterine contractions, relaxin may influence the timing of parturition. Two previously characterized orphan receptors designated relaxin receptor 1 (LGR7) and 2 (LGR8) bind relaxin in several tissues, including reproductive tissues, brain, and heart. Upon ligand binding, the relaxin receptors activate adenylate cyclases through Gs proteins. Expression of the relaxin receptors in tissues other than reproductive ones suggests that they have additional physiological functions, such as regulating blood pressure and controlling vascular volume in the heart. |
Synonyms | G-protein coupled receptor 106, GPR106, GREAT, LGR8 |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Neuroactive ligand-receptor interaction |
Documents
Product Manuals |
FAQs |
SDS |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.