CLCC1 Rabbit Polyclonal Antibody

CAT#: AP01467PU-N

CLCC1 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of CLCC1 Antibody (Cat.-No AP01467PU-N) in extracts from RAW264.7 cell.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of CLCC1 protein. (region surrounding Asp429)
• Formulation: Phosphate buffered saline (PBS) pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Predicted Protein Size: ~ 62 kDa
• Gene Name: Homo sapiens chloride channel CLIC like 1 (CLCC1), transcript variant 1
• Database Link:
  Entrez Gene 23155 Human
• Background: Chloride channels (CLCs) regulate cellular traffic of chloride ions, a critical component of all living cells. CLCs are involved in membrane potential stabilization, signal transduction, cell volume regulation and organic solute transport. CLCC1 (Chloride channel CLIC-like protein 1), also known as MCLC (Mid-1-related chloride channel) or KIAA0761, is a 551 amino acid multi-pass membrane protein that belongs to the chloride channel MCLC family. CLCC1 is related to the Saccharomyces cerevisiaeprotein Mid-1 and is believed to function as an intracellular chloride channel that is expressed in lung, brain, muscle, liver and testis. Localizing to intracellular compartments such as the Golgi apparatus, the endoplasmic reticulum (ER) and the nuclear envelope, CLCC1 is expressed as four isoforms due to alternative splicing events, namely hMCLC-1, hMCLC-2, hMCLC-3 and hMCLC-4.
• Synonyms: KIAA0761, MCLC

Reference Data

• Protein Families: Ion Channels: Other, Transmembrane