GNAL Rabbit Polyclonal Antibody

CAT#: AP01477PU-N

GNAL rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of G alpha olf antibody (Cat.-No AP01477PU-N) in extracts from LOVO cells.

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  Immunohistochemistry analyzes of G alpha olf antibody (Cat.-No AP01477PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 50-100 of Human Gα olf.
• Specificity: This antibody detects endogenous levels of G alpha olf protein.
• Formulation: Phosphate Buffered Saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (95% by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~40 kDa
• Gene Name: Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type (GNAL), transcript variant 3
• Database Link:
  Entrez Gene 14680 MouseEntrez Gene 24611 RatEntrez Gene 2774 Human
• Background: Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (e.g. adenyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein α, β and γ polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their α subunits, since these proteins bind and hydrolyze GTP, and most obviously regulate the activity of the best studied effectors. The Gs subfamily of Gα subunits includes two closely related proteins, Gα s and Gα olf, which, respectively, stimulate adenylate cyclase and mediate response to olfactory stimuli.
• Synonyms: GNAL

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Calcium signaling pathway, Olfactory transduction