Vsx2 (C-term) Sheep Polyclonal Antibody

CAT#: AP05111PU-N

Vsx2 (C-term) sheep polyclonal antibody, Purified

Product Images

Western blot analysis using anti-Chk10 (CT) antibody at 1 ug/ml on rat liver (A), retina tissue lysate (B), mouse liver (C) and retina (D) tissue lysate.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 0.5-1.0 mg/ml.
  Detects a 46 kDa band in Mouse and Rat retinal tissue lysates.
  Immunohistochemistry on Frozen Sections.
  Suitable for use againt recombinant proteins conjugated to OVA, GST, His tags and others.
• Reactivities: Mouse, Rat
• Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A recombinant protein corresponding to amino acids 264 to 361 derived from the C terminal of the Human Chx10 protein conjugated to KLH.
• Specificity: This antibody recognizes chx 10 (C-Term). Other species not tested.
• Formulation: PBS containing 0.08% Sodium Azide as preservative.
  State: Purified
  State: Liquid purified IgG fraction.
• Purification: Ammonium Sulfate Precipitation
• Predicted Protein Size: 46 kDa
• Gene Name: Mus musculus visual system homeobox 2 (Vsx2), transcript variant 2
• Database Link:
  Entrez Gene 171360 RatEntrez Gene 12677 Mouse
• Background: Chx10 is a 46kDa homeodomain protein of the paired-like class that is essential for development of the mammalian eye. Mutations in Chx10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina Chx10 is expressed in retinal progenitors, while in the mature retina, Chx10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the Chx10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. Chx10 is also expressed in the developing brainstem, thalamus, and spinal cord.
• Synonyms: HOX10