SH2D1A Rabbit Polyclonal Antibody

CAT#: AP05121PU-N

SH2D1A rabbit polyclonal antibody, Purified

Product Images

Western blot analysis using SAP antibody on NK-92 cell lysate at 10 ug/ml).

Specifications

Product Data

• Applications: IP, WB
• Recommended Dilution: Western Blot: 5 - 10 µg/ml.
  Immunoprecipitation.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full-length recombinant SAP protein
• Specificity: This antibody reacts to SH2D1A.
• Formulation: Phosphate buffered saline with 0.08% sodium azide
  State: Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Storage: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens SH2 domain containing 1A (SH2D1A), transcript variant 2
• Database Link:
  Entrez Gene 4068 Human
• Background: SLAM (Signaling Lymphocyte-Activation Molecule) is a glycosylated type-I transmembrane protein which is present on the surface of B and T cells. SLAM is a high-affinity self-ligand which, when triggered, co-activated B or T lymphocyte responses and is considered to be important in bi-directional T - B cell stimulation. SAP (SLAM-Associated Protein) has been determined to be a 15 kDa protein. SAP is believed to the genetic defect which cauases X-linked Lymphoproliferative Syndrome (XLP). SAP is thought to bind to SLAM by the SH2 domain of the SAP protein. Binding of SAP to the SLAM protein blocks the binding of SHP-2 to the phosphorylated SLAM protein which causes XLP.
• Synonyms: DSHP, SAP, SH2 domain-containing protein 1A, SLAM-associated protein, T-cell signal transduction molecule SAP, Duncan disease SH2-protein

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Natural killer cell mediated cytotoxicity