SH2D1A Rabbit Polyclonal Antibody

CAT#: AP05121PU-N

SH2D1A rabbit polyclonal antibody, Purified


USD 360.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications IP, WB
Recommended Dilution Western Blot: 5 - 10 µg/ml.
Immunoprecipitation.
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Full-length recombinant SAP protein
Specificity This antibody reacts to SH2D1A.
Formulation Phosphate buffered saline with 0.08% sodium azide
State: Purified
State: Liquid purified Ig
Concentration lot specific
Storage The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens SH2 domain containing 1A (SH2D1A), transcript variant 2
Background SLAM (Signaling Lymphocyte-Activation Molecule) is a glycosylated type-I transmembrane protein which is present on the surface of B and T cells. SLAM is a high-affinity self-ligand which, when triggered, co-activated B or T lymphocyte responses and is considered to be important in bi-directional T - B cell stimulation. SAP (SLAM-Associated Protein) has been determined to be a 15 kDa protein. SAP is believed to the genetic defect which cauases X-linked Lymphoproliferative Syndrome (XLP). SAP is thought to bind to SLAM by the SH2 domain of the SAP protein. Binding of SAP to the SLAM protein blocks the binding of SHP-2 to the phosphorylated SLAM protein which causes XLP.
Synonyms DSHP, SAP, SH2 domain-containing protein 1A, SLAM-associated protein, T-cell signal transduction molecule SAP, Duncan disease SH2-protein
Reference Data
Protein Families Druggable Genome
Protein Pathways Natural killer cell mediated cytotoxicity

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.