sphingosine 1 phosphate phosphatase 1 (SGPP1) Rabbit Polyclonal Antibody

CAT#: AP05169PU-N

sphingosine 1 phosphate phosphatase 1 (SGPP1) rabbit polyclonal antibody, Aff - Purified

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1:200; Tissue lysate should be used at 10-50 µg/lane.
  Positive Control: Human brain lysate.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from the sphingosine 1-phosphate phosphatase 1 protein.
• Specificity: This antibody reacts to Sphingosine 1-Phosphate Phosphatase 1.
• Formulation: Phosphate buffered saline with 0.08% sodium azide
  State: Aff - Purified
  State: Liquid purified Ig
• Concentration: Lot specific
• Gene Name: Homo sapiens sphingosine-1-phosphate phosphatase 1 (SGPP1)
• Database Link:
  Entrez Gene 81537 Human
• Background: Sphingosine 1-phosphate (S1P) is a highly bioactive lipid that has a myriad of biological effects both intracellularly as a second messenger and extracellularly by binding to the S1P(1-5)/G-protein-coupled receptors of the endothelial differentiation gene family. Intracellularly, at least two enzymes, sphingosine kinase (1 and 2) and S1P phosphatase, regulate the activity of S1P by governing the phosphorylation of S1P. Regulation of hS1Pase1 with the resultant changes in cellular and secreted S1P has important implications in cell proliferation, angiogenesis and apoptosis.
• Synonyms: Sphingosine-1-phosphatase 1, SPPase1

Reference Data

• Protein Families: Druggable Genome, Phosphatase, Transmembrane
• Protein Pathways: Sphingolipid metabolism