Col1a1 Rabbit Polyclonal Antibody

CAT#: AP05388PU-N

Col1a1 rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA, IF, IHC, R
• Recommended Dilution: ELISA: 1/100-1/400.
  Immunofluorescence: 1/50-1/100.
  Radioimmunoassays.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections: 1/250-1/1000.
• Reactivities: Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Native type I Collagen from Mouse skin.
• Specificity: This antibody is specific for Mouse Collagen type I.
  Less than 1% cross reactivity has been observed with Mouse Collagen, types II, VI and III and Human, Chicken and Rat Collagen, type I.
• Formulation: Phosphate buffered saline containing 0.09% Sodium Azide as preservative.
  State: Purified
  State: Liquid purified Ig fraction
• Purification: Affinity Chromatography
• Gene Name: Mus musculus collagen, type I, alpha 1 (Col1a1)
• Database Link:
  Entrez Gene 12842 Mouse
• Background: Collagens are highly conserved throughout evolution and are characterised by an uninterrupted "Glycine X Y" triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon. Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for Platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.
• Synonyms: COL1A1, COL1A2, Alpha-1 type I collagen, Alpha-2 type I collagen