CBSL Rabbit Polyclonal Antibody

CAT#: AP17189PU-N

CBSL rabbit polyclonal antibody

Product Images

Western blot analysis of CBS Antibody (Center) in mouse kidney tissue lysates (35 ug/lane). CBS (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1:100 - 1:500.
  ELISA: 1:1,000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the Center region of human CBS
• Specificity: This antibody detects CBS at Center.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Purified through a protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens cystathionine-beta-synthase (CBS), transcript variant 1
• Database Link:
  Entrez Gene 12411 MouseEntrez Gene 102724560 Human
  UniProt ID P0DN79
• Background: CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. This protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria.
• Synonyms: Cystathionine beta-synthase, Serine sulfhydrase, Beta-thionase
• Note: Molecular weight: 60587 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cysteine and methionine metabolism, Glycine, serine and threonine metabolism, Metabolic pathways, Selenoamino acid metabolism