Carboxypeptidase B2 (CPB2) Rabbit Polyclonal Antibody

CAT#: AP17235PU-N

Carboxypeptidase B2 (CPB2) rabbit polyclonal antibody

Product Images

Western blot analysis of CPB2 antibody (Center E134) in Jurkat cell line lysates (35 ug/lane). CPB2 (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected between 119~148 amino acids from the Center region of Human CPB2
• Specificity: This antibody detects CPB2 (aa 126~156).
• Formulation: PBS with 0.09% (W/V) Sodium Azide as preservative.
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens carboxypeptidase B2 (CPB2), transcript variant 1
• Database Link:
  Entrez Gene 1361 Human
• Background: Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for its gene and its promoter region.
• Synonyms: CPB2, Carboxypeptidase U, TAFI, CPU, pCPB
• Note: Calculated Molecular Weight: 48412 Da

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Complement and coagulation cascades