SIGLECL1 (SIGLEC12) (C-term) Rabbit Polyclonal Antibody

CAT#: AP18196PU-N

SIGLECL1 (SIGLEC12) (C-term) rabbit polyclonal antibody

Product Images

Western blot analysis of SIGLEC12 Antibody (C-term) in mouse bladder tissue lysates (35ug/lane). SIGLEC12 (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/50 - 1/100.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of human SIGLEC12
• Specificity: This antibody reacts to SIGLEC12.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), transcript variant 1
• Database Link:
  Entrez Gene 89858 Human
• Background: Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. SIGLEC12 is a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. This protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor.
• Synonyms: Siglec-12, SIGLECL1, Siglec-L1, SLG

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency, Transmembrane